What Is 2-Bromophenylboronic Acid CAS 244205-40-1 Used For?

2-Bromophenylboronic acid, CAS 244205-40-1, is an aromatic boronic acid used mainly as a bifunctional building block in organic synthesis. It contains both a boronic acid group and a bromine substituent, giving chemists two potential points for further functionalization. In particular, the boronic acid group can serve as a coupling partner in Suzuki–Miyaura reactions, while the bromine may be retained for a later transformation. For research and manufacturing teams, this makes the compound useful when a synthesis plan calls for sequentially building bonds on an aromatic ring.

You can find more information on our web, so please take a look.

Key Takeaways

• Its principal synthetic use is as an aryl boronic acid coupling partner, especially in Suzuki–Miyaura chemistry.
• The boronic acid and aryl bromide groups provide distinct functional handles, which may enable sequential transformations.
• It is an intermediate or research reagent, not a finished pharmaceutical, agrochemical, or material.
• Buyers should confirm the required grade, assay, packaging, documentation, and batch availability before ordering.

Core Functions in Organic Synthesis

Suzuki–Miyaura coupling partner

The boronic acid group can participate in palladium-catalyzed Suzuki–Miyaura cross-coupling with a suitable organic halide or related coupling partner. This reaction can form a carbon–carbon bond and introduce the 2-bromophenyl-derived fragment into a larger molecule. The exact reaction outcome depends on the substrate, catalyst system, base, solvent, and conditions selected by the chemist. We recommend treating the compound as a building block whose suitability must be assessed within the specific route, rather than assuming one set of conditions will fit every application.

Two functional handles for stepwise synthesis

A notable feature of this molecule is that it carries both a boronic acid group and a bromine atom on the aromatic ring. A route may use the boronic acid group in one coupling step while preserving the aryl bromide for a later reaction. This approach can help chemists design sequential substitutions and construct more complex biaryl or other aromatic structures. Whether the bromine remains intact depends on the chosen reaction conditions and the reactivity of the other components.

Common Application Scenarios

Pharmaceutical and medicinal chemistry research

In discovery chemistry, researchers may use 2-bromophenylboronic acid to prepare analogues containing a substituted phenyl group. A retained bromine can offer an additional site for subsequent diversification, which can be useful when exploring structure–activity relationships. These are synthetic research applications; the compound itself should not be understood as an approved drug ingredient or as evidence of a therapeutic effect. Suitability for a particular target or route must be established experimentally.

Agrochemical and fine-chemical intermediate synthesis

Teams developing crop-protection or other fine-chemical molecules may consider this building block when their target structure requires an ortho-brominated aromatic fragment or a related substituted ring. It can also be evaluated for preparing intermediates used in multistep synthesis. The value of the material depends on the target molecule, route efficiency, and compatibility with downstream steps. We advise buyers to share the intended use and key route constraints when requesting a supply assessment.

Academic and process-development work

Universities, contract research organizations, and process-development groups may use the compound to test reaction sequences or prepare reference intermediates. At small scale, it can support route screening; at larger scale, teams need to review factors such as impurity profile, handling, reaction waste, and reproducibility. A successful small-scale reaction does not by itself establish commercial-scale performance. Scale-up decisions should be based on route-specific evaluation and appropriate process-safety review.

Maison Chemical Product Page

Identity and Quantity Reference

The product is identified by CAS 244205-40-1 and the chemical name 2-bromophenylboronic acid. Its molecular formula is C₆H₆BBrO₂, and its calculated molecular weight is 200.83 g/mol. The theoretical mass for 1 mmol is therefore 200.83 mg, before accounting for assay, moisture, handling loss, or any other correction required by the procedure.

The 10 mmol figure is a mathematical conversion using the molecular weight, not a product pack size or a recommended reaction scale. Actual weighing should follow the assay and calculation procedure used by the customer’s laboratory. For procurement, request the current specification and batch documentation rather than relying on a theoretical calculation as a substitute for quality information.

Material Options and Specification Checks

For a specialty intermediate, buyers should distinguish between chemical identity and the commercial specification offered for a particular batch. A product name and CAS number help establish what is being requested, but they do not specify assay, impurity limits, appearance, packaging, or analytical methods. These details can vary by supplier and batch, so they should be confirmed in writing before order placement. If a project requires a specific test method or impurity threshold, include it in the inquiry.

Information to confirm before purchase

• Identity: Confirm the product name, CAS number, and molecular formula match the intended material.
• Quality requirements: State the required assay or other acceptance criteria and ask which documentation is available for the offered batch.
• Quantity and packaging: Specify the amount required, intended use, and any packaging or handling preferences.
• Regulatory and shipping needs: Identify destination-country requirements and request confirmation of applicable transport and documentation details.
• Timing: Ask whether the material is available from current stock or requires a production or sourcing schedule.

How Buyers Can Assess Supplier Fit

The best supplier choice depends on more than the quoted unit price. Buyers should compare the stated specification, document availability, packaging options, order quantity, delivery estimate, and communication around any technical questions. For a development program, consistency between repeat orders may matter; for an early screening project, a smaller quantity and clear identity documentation may be the immediate priorities. Ask suppliers to distinguish confirmed information from items that remain subject to batch or logistics confirmation.

Maison Chemical supports B2B inquiries for 2-bromophenylboronic acid and related chemical sourcing needs. When you contact us, provide the requested quantity, destination, required specification, and intended application so we can review the inquiry efficiently. We can discuss available product information and confirm the relevant supply details for the specific quotation. Availability, lead time, documentation, and commercial terms should be confirmed for each order.

Conclusion: When Is This Compound the Right Choice?

2-Bromophenylboronic acid CAS 244205-40-1 is primarily used as a synthetic building block for carbon–carbon bond formation and as a potentially useful intermediate for sequential aromatic functionalization. It is most relevant when a route can use the boronic acid group for coupling and may benefit from retaining the bromine as a second reaction handle. Its usefulness depends on substrate compatibility, reaction design, and the specification required by the project. To take the next step, define your application and quality requirements, then request batch-specific product and supply information from Maison Chemical.

Are you interested in learning more about 2-Bromophenylboronic acid CAS 244205-40-1? Contact us today to secure an expert consultation!