4-Benzyloxy-2-methylphenylboronic Acid CAS 847560-49-0: Product Information, Applications, and Sourcing Guide

4-Benzyloxy-2-methylphenylboronic acid, CAS 847560-49-0, is an arylboronic acid building block for evaluating in synthetic chemistry projects, including routes that use carbon–carbon cross-coupling. Its structure combines a boronic acid group with a methyl substituent and a benzyloxy-protected oxygen substituent. The calculated molecular formula is C₁₄H₁₅BO₃, with a molar mass of approximately 242.08 g/mol. If you are considering this material for a project, confirm the required specification, documentation, quantity, and delivery timing with your supplier before ordering.

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Key Takeaways

• This compound is a substituted arylboronic acid identified by CAS 847560-49-0.
• Its boronic acid group makes it a candidate building block for suitable cross-coupling chemistry; the benzyloxy group may serve as a protected oxygen substituent, depending on the planned route.
• Theoretical mass conversions are approximately 242.1 mg per 1 mmol, 100 mg per 0.413 mmol, and 1 g per 4.13 mmol. These calculations do not account for assay or purity.
• For procurement, assess identity, assay, impurity limits, packaging, analytical documentation, MOQ, and lead time against your own project requirements.

Who This Guide Is For

This guide is intended for medicinal and process chemists, research laboratories, chemical sourcing teams, and manufacturers evaluating 4-Benzyloxy-2-methylphenylboronic acid as a specialty intermediate. It is useful when you need to establish whether the compound’s substitution pattern fits a proposed synthesis or when you are preparing a supplier inquiry. It is not a substitute for route-specific validation or a product-specific certificate of analysis.

Buyers at different project stages may need different levels of information. A discovery team may first need a small quantity for feasibility work, while a process group may need tighter impurity controls, repeatable supply, and a larger-scale quotation. Identify your stage and intended use before comparing offers so the supplier can respond with relevant details.

Product Overview and Structural Context

What the Compound Is

The name describes a phenylboronic acid ring bearing a benzyloxy substituent at the 4-position and a methyl substituent at the 2-position, relative to the boronic acid-bearing carbon. The molecule therefore contains one boronic acid group per molecule, alongside an aromatic ring and a benzyl ether. The CAS number is a useful identifier for sourcing, but buyers should still confirm that the supplier’s product description and analytical documentation match the intended compound.

The molar mass above is a calculated value derived from the stated molecular formula, rather than a measured assay or release result. For stoichiometric planning, 1 mmol corresponds to approximately 242.1 mg at 100% material content. On the same theoretical basis, 100 mg corresponds to about 0.413 mmol and 1 g to about 4.13 mmol; adjust actual weighing calculations if the reported assay or water content requires it.

Functional Groups and Route Considerations

Arylboronic acids are commonly considered in palladium-catalyzed Suzuki–Miyaura coupling routes, where an aryl group can be coupled with a suitable reaction partner. Whether this specific substrate performs as needed depends on the partner, catalyst system, solvent, base, and reaction conditions. We recommend treating its suitability as a route-development question rather than assuming a particular yield or operating condition.

The benzyloxy substituent can be relevant when a route requires an oxygen substituent to remain protected during an earlier transformation and be unmasked at a later stage. Whether benzyl deprotection is compatible with the rest of a molecule must be evaluated for the specific substrate and route. The ortho methyl substituent may also affect steric environment, so reaction performance should be confirmed experimentally for the intended coupling.

Potential Applications and Application Matching

Potential uses include research and development of substituted biaryl compounds, medicinal chemistry intermediates, and other molecules where this particular aromatic substitution pattern is desired. These are application directions based on the compound’s functional groups, not claims of validated performance in a named process. A useful first check is to compare the compound’s substitution pattern with the target structure and determine whether the boronic acid is the appropriate coupling partner for the planned route.

For early-stage screening, consider the compound when the desired product retains the methyl group and requires a route-compatible oxygen substituent at the corresponding ring position. For process development, also assess reaction selectivity, impurity formation, work-up, and compatibility with later transformations. If the route depends on a sensitive catalyst or a narrow impurity profile, ask for relevant analytical details before moving from feasibility studies to larger quantities.

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Buyer Selection Framework

Confirm Identity and Required Specifications

Begin by confirming the product name, CAS number, molecular formula, and intended structure. Then specify the quality attributes that matter for your use, such as assay or purity method, identification tests, residual solvents, water content, and limits for relevant impurities. Do not assume that two quotations with the same CAS number offer identical specifications or analytical methods.

Request a current product specification and, where available for the quoted lot, a certificate of analysis. Review the analytical methods and acceptance criteria rather than relying only on a headline purity figure. For regulated or tightly controlled projects, define your documentation and change-notification expectations before purchase.

Match Quantity, Packaging, and Logistics to the Project

Share the quantity needed for evaluation and any anticipated follow-on demand, while distinguishing confirmed requirements from forecasts. Packaging should be suitable for the planned handling, storage, and transport conditions; ask the supplier to state the proposed pack size and any applicable handling guidance. Storage conditions should be taken from product-specific documentation, not inferred from the compound class alone.

MOQ and lead time can vary with available inventory, batch status, requested quantity, packaging, and destination. Because these details are not universal product constants, request a current quotation that states the offered quantity, price basis, availability, estimated dispatch timing, and shipping terms. For repeat purchases, ask whether the proposed supply route and specification can be maintained for future orders.

Pricing, MOQ, and Lead-Time Considerations

Price comparisons are meaningful only when the quoted material and service scope are comparable. Check whether the offer covers the same specification, quantity, packaging, analytical documents, and shipping basis. A lower unit price may not meet a project’s quality or documentation requirements, while a more detailed offer should be evaluated against its actual deliverables rather than assumed benefits.

When you request a quote, provide the target quantity, destination country, required delivery window, and any specification or document requirements. If your project is exploratory, ask whether a smaller evaluation quantity is available and whether the supplier can quote a potential scale-up separately. We do not recommend relying on generic lead-time estimates without confirming current availability for the specific order.

Supplier Evaluation Checklist

• Identity: Does the offer clearly identify 4-Benzyloxy-2-methylphenylboronic acid and CAS 847560-49-0?
• Specification: Are assay, identification, impurity, and other required criteria stated clearly?
• Documentation: Can the supplier provide the available lot-specific analytical documents and explain the methods used?
• Commercial terms: Are MOQ, quantity, price basis, packaging, and estimated lead time explicit?
• Supply fit: Can the supplier discuss your expected demand and confirm whether the offered supply arrangement fits the project?

Maison Chemical supports B2B inquiries for specialty chemical sourcing, including requests that require confirmation of product specifications, quantities, and shipping details. Share your intended application at a level appropriate for your project, along with the target specification and delivery destination. We can then review the request and clarify what product and documentation information is available for the proposed supply.

Conclusion and Next Steps

4-Benzyloxy-2-methylphenylboronic acid CAS 847560-49-0 is a substituted arylboronic acid that may fit routes requiring this specific aromatic pattern and a boronic acid coupling handle. Its potential role in coupling chemistry and the use of its benzyloxy group depend on the reaction partner, route design, and experimental validation. The calculated molar mass is approximately 242.08 g/mol, which can support initial stoichiometric planning but does not replace lot-specific assay information.

To determine whether the product is right for your project, compare its structure with your target, define the specification and documents you need, and confirm current MOQ, price, and lead time. Contact Maison Chemical with your requested quantity, destination, and quality requirements to begin a product-specific sourcing discussion. This gives your team a practical basis for evaluating fit before placing an order.

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