2,4,6-Trifluorophenylboronic Acid CAS 182482-25-3: Uses, Specifications, and Buying Guide

2,4,6-Trifluorophenylboronic acid, CAS 182482-25-3, is a fluorinated aryl boronic acid used primarily as a building block in synthetic chemistry. Its most important role is participation in palladium-catalyzed Suzuki–Miyaura coupling, where the aryl group can be transferred to a suitable halide or related electrophile to form biaryl structures. I recommend evaluating this material by identity, assay, water content, packaging, documentation, and supplier reliability rather than by price alone. Maison Chemical supplies this type of organic boronic acid for research, process development, and specialty synthesis inquiries.

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Key Takeaways

• 2,4,6-Trifluorophenylboronic acid is an aryl boronic acid intermediate identified by CAS 182482-25-3.
• Its molecular formula is commonly represented as C₆H₄BF₃O₂, with a calculated molecular weight of approximately 175.90 g/mol.
• The compound is most relevant to cross-coupling chemistry and the preparation of fluorinated aromatic targets.
• Buyers should confirm assay, water content, appearance, analytical data, packaging, MOQ, and lead time before placing an order.
• Maison Chemical can support product selection, quotation preparation, export coordination, and documentation review according to project requirements.

What Is 2,4,6-Trifluorophenylboronic Acid?

2,4,6-Trifluorophenylboronic acid is an organoboron compound containing a phenyl ring substituted with three fluorine atoms and a boronic acid group. The fluorine atoms are positioned at the 2, 4, and 6 positions relative to the boronic acid functionality. The boronic acid group provides a practical reaction handle for carbon–carbon bond formation, while the fluorinated ring can contribute distinctive electronic and metabolic properties to downstream molecules.

The product is also described as [2,4,6-trifluorophenyl]boronic acid in some technical documents. Its CAS number is 182482-25-3, and its approximate molecular weight is 175.90 g/mol. Because naming conventions and catalog descriptions can vary, I advise buyers to confirm the CAS number, molecular formula, molecular weight, and structure together on the quotation and certificate of analysis.

Common Uses and Application Scenarios

Suzuki–Miyaura Cross-Coupling

The principal use of this compound is as an aryl donor in Suzuki–Miyaura coupling. In a typical reaction design, the boronic acid reacts with an aryl, heteroaryl, or vinyl halide under a suitable catalyst and base system. The result can be a biaryl or related carbon–carbon bonded product, although the exact outcome depends on the reaction partners, catalyst, solvent, temperature, and work-up conditions.

This reaction utility makes 2,4,6-trifluorophenylboronic acid relevant to medicinal chemistry, agrochemical research, material research, and fine chemical development. It can help introduce a sterically congested, electron-influenced fluorinated aromatic fragment into a target structure. I would not treat the material as a universal coupling reagent, however, because substrate compatibility and boronic acid stability must be confirmed experimentally.

Pharmaceutical and Discovery Chemistry

Fluorinated aromatic groups are frequently explored in discovery programs because fluorine substitution can influence molecular size, lipophilicity, conformation, and electronic behavior. The presence of three fluorine atoms at the 2, 4, and 6 positions creates a defined substitution pattern that may be useful when a project requires a highly specific aromatic motif. The compound is therefore best viewed as a research intermediate rather than as an active pharmaceutical ingredient.

Specialty Intermediates and Materials Research

Researchers may also use this boronic acid to prepare fluorinated aromatic intermediates for electronic materials, ligands, probes, and other functional molecules. The suitability of the product depends on the final structure and the required impurity profile. For scale-up work, I recommend confirming not only reaction performance but also isolation behavior, residual metals, water content, and lot-to-lot consistency.

Technical Specifications Buyers Should Review

The starting specification should identify the product as 2,4,6-trifluorophenylboronic acid with CAS 182482-25-3. The commonly used molecular formula is C₆H₄BF₃O₂, and the approximate molecular weight is 175.90 g/mol. These identity details are useful for purchasing, inventory control, reaction calculations, and analytical method setup.

A commercial quotation may state a purity target such as 98% or higher, but I recommend treating that number as a specification to verify rather than an assumption about every lot. Buyers should request the actual certificate of analysis for the offered batch and review the method used to determine assay. If the compound will enter a regulated or sensitive process, additional testing may be required by the buyer’s quality system.

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How to Select the Right Supply Option

1. Define the Intended Use

First, identify whether the requirement is for route scouting, analytical research, medicinal chemistry, process development, or manufacturing. Early-stage experiments may prioritize availability and a suitable research-grade assay, while process work may require tighter control of water, metals, residual solvents, and batch documentation. The intended application determines which specifications are essential.

2. Match Quantity to Project Stage

Purchase quantity should reflect the development phase and expected consumption. A small pack can reduce initial inventory exposure during reaction screening, whereas larger packaging may be more practical after the route and quality requirements are established. I recommend asking for quotations at multiple quantities so that the buyer can compare unit cost, MOQ, packaging efficiency, and remaining shelf-life expectations.

3. Evaluate Documentation Before Ordering

At minimum, request a product specification, certificate of analysis, safety data sheet, and packaging information. For international procurement, confirm the commercial invoice requirements, export documentation, transport classification where applicable, and the consignee’s import responsibilities. Documentation should be reviewed before shipment rather than after the material arrives.

4. Confirm Supply Timing and Batch Availability

Lead time can vary according to stock status, batch release, quantity, packaging, and destination. I recommend asking whether the quoted material is available from an existing batch or requires production scheduling. A realistic purchase decision should include both the quoted lead time and a reasonable allowance for quality review, shipping, customs, and receiving inspection.

Application Matching and Practical Limitations

This compound is a strong candidate when a project specifically requires a 2,4,6-trifluorinated aryl fragment and a boronic acid coupling handle. It may be less suitable when the target route is incompatible with boronic acid functionality, when a different regioisomer is required, or when the process has unusually strict impurity controls that have not been established for the selected batch. The correct choice should be based on the target structure and reaction evidence, not simply on the presence of fluorine.

Boronic acids can show variable behavior depending on storage, moisture exposure, concentration, and reaction conditions. For that reason, I recommend following the supplier’s storage guidance, keeping the container properly closed, and using an internal incoming inspection procedure. If the material is intended for a long development campaign, ask whether reserve samples, repeat-batch data, or additional analytical support can be provided.

Supplier Evaluation Checklist

• Can the supplier confirm CAS 182482-25-3 and provide a batch-specific certificate of analysis?
• Is the quoted assay suitable for the intended reaction and development stage?
• Can the supplier provide information on water, residual solvents, and relevant impurities?
• Are MOQ, pack sizes, lead time, and shipping terms clearly stated?
• Can the supplier support repeat orders with consistent documentation?
• Does the supplier communicate clearly about packaging, export paperwork, and technical questions?

Maison Chemical approaches this product as a B2B chemical supply requirement rather than a simple catalog transaction. We can help buyers clarify the required grade, quantity, documentation, packaging, and delivery destination before preparing a quotation. Where a project has specific assay, moisture, impurity, or analytical requirements, those points should be discussed during the inquiry so that the offered material can be evaluated against the actual application.

Conclusion: How to Buy with Confidence

2,4,6-Trifluorophenylboronic acid CAS 182482-25-3 is a fluorinated aryl boronic acid mainly used to construct carbon–carbon bonds in synthetic research, especially through Suzuki–Miyaura coupling. Its approximate molecular weight is 175.90 g/mol, but molecular weight alone is not enough to qualify a supply. Buyers should confirm identity, assay, water content, impurity information, packaging, batch documentation, MOQ, and lead time.

The next practical step is to send Maison Chemical your required quantity, target application, desired purity, destination, and documentation needs. We can then review the specification and provide a project-appropriate quotation for 2,4,6-trifluorophenylboronic acid. This structured approach helps reduce sourcing uncertainty and supports a more reliable transition from laboratory screening to repeat procurement.

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