What Is 4-Aminophenylboronic Acid Picol Ester CAS 214360-73-3? Uses, Properties, and Supplier Information

4-Aminophenylboronic acid picol ester, listed under CAS 214360-73-3, is an aromatic boronic ester used as a synthetic building block in organic and medicinal chemistry. Its structure combines a para-aminophenyl group with a protected boron-containing functionality, giving chemists a practical handle for carbon–carbon bond formation and further molecular modification. I recommend treating “picol ester” as a nomenclature point that should be confirmed against the supplier’s certificate of analysis because commercial catalogs may use closely related names, including “pinacol ester,” for boronic ester products.

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In practical terms, this material is usually evaluated for identity, assay, water content, residual solvents, appearance, and suitability for the customer’s planned reaction. It is not generally purchased as a final active ingredient; instead, it is selected as an intermediate or research compound for synthesis. At Maison Chemical, I help buyers confirm the exact structure, documentation package, quantity requirement, and intended application before quotation.

What Is 4-Aminophenylboronic Acid Picol Ester?

4-Aminophenylboronic acid picol ester is an aryl boronic ester containing one boron atom and one para-position amino group on an aromatic ring. The amino group provides a useful site for derivatization, protection, salt formation, or incorporation into larger pharmaceutical and materials molecules. The boronic ester group acts as a protected form of aryl boronic acid and can participate in transition-metal-catalyzed coupling chemistry under suitable conditions.

The CAS number associated with the requested product is 214360-73-3. Because boronic ester nomenclature can vary between databases and suppliers, I advise buyers to compare the CAS number, chemical name, structural drawing, molecular formula, and molecular weight before placing an order. A supplier should also confirm whether the requested “picol ester” wording refers to the intended cyclic boronic ester structure or to a related catalog designation.

Core Functions in Chemical Synthesis

Carbon–Carbon Bond Formation

The principal value of this type of compound is its aryl boronic ester functionality. Under an appropriate palladium-catalyzed coupling protocol, aryl boronic esters can react with aryl or heteroaryl halides to form biaryl products. The exact conversion depends on the reaction partners, catalyst system, base, solvent, temperature, water content, and substrate sensitivity, so I do not treat the presence of a boronic ester as a guarantee of reaction performance.

Intermediate for Molecular Diversification

The para-amino group provides a second functional handle that can be used in downstream synthesis. Chemists may protect the amine before coupling, transform it into an amide or urea, or use it as part of a heterocycle-building sequence. This combination of an aniline-type group and a boronic ester can support efficient preparation of substituted aromatic libraries.

Building Block for Research and Development

Research teams may use this compound during medicinal chemistry, process development, and advanced intermediate screening. Its value is highest when the project requires a defined aromatic substitution pattern and a boron-based coupling handle in the same molecule. I recommend confirming compatibility with the planned route at small scale before committing to larger procurement.

Application Scenarios

• Medicinal chemistry: preparation of biaryl, heteroaryl, amide, urea, and related analogues.
• Pharmaceutical intermediate research: route scouting and synthesis of advanced aromatic intermediates.
• Custom molecule development: rapid diversification of para-substituted aromatic structures.
• Materials and functional molecule research: exploratory synthesis of boron-containing aromatic compounds.
• Process chemistry: evaluation of scalable coupling sequences after laboratory feasibility is established.

These applications describe common synthetic roles rather than guaranteed end uses. The correct grade depends on whether the buyer needs exploratory research material, a higher-purity intermediate, or material suitable for a controlled process-development campaign. I recommend sharing the reaction scheme or target specification with the supplier whenever possible.

Types and Material Options to Consider

Buyers may encounter several related products, including the free aryl boronic acid, a pinacol-type boronic ester, other cyclic boronic esters, and protected or unprotected aniline derivatives. These materials are not automatically interchangeable because their stability, solubility, hydrolysis behavior, purification profile, and reaction performance can differ. The name alone is therefore insufficient for final material selection.

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For CAS 214360-73-3, I suggest requesting a structure confirmation before comparing quotations. The minimum confirmation package should include the CAS number, chemical structure, molecular formula, molecular weight, assay method, and representative analytical data. If the customer’s process is sensitive to water or hydrolysis, moisture data and recommended storage conditions should also be reviewed.

Key Specifications Buyers Should Review

When a customer requests a quotation, I normally separate the technical specification from the commercial specification. Technical requirements may include a minimum assay, a water limit, an analytical method, and packaging format, while commercial requirements may include quantity, delivery destination, documentation, and preferred lead time. For a practical first evaluation, buyers often compare sample quantities such as 0.1 g, 1 g, and 5 g, although the suitable amount depends on the project stage and supplier availability.

How to Select a Reliable Supplier

Confirm the Exact Product Before Comparing Price

The first step is to verify that the offered material matches CAS 214360-73-3 and the required structural drawing. I recommend asking for a current specification sheet and a representative certificate of analysis rather than relying only on a marketplace title. This simple check can prevent confusion between an aryl boronic acid, a boronic ester, and a different aminophenyl isomer.

Review Quality and Documentation

A suitable supplier should be able to explain the analytical methods used for identity and purity testing. Depending on the project, the documentation package may include a certificate of analysis, safety data sheet, packing information, and batch-specific analytical records. I advise buyers to define whether they need a research-grade specification or a more controlled intermediate specification before production planning.

Assess Packaging, Logistics, and Communication

Boronic ester products should be packed in a way that limits exposure to moisture and contamination. The buyer should confirm the container size, inner packaging, labeling, storage guidance, and transport conditions before shipment. I also recommend evaluating response quality: a supplier that answers structure and documentation questions clearly is generally easier to manage during scale-up and repeat purchasing.

Maison Chemical Supplier Support

At Maison Chemical, I support B2B customers sourcing 4-aminophenylboronic acid picol ester CAS 214360-73-3 for research, intermediate development, and export projects. My role is to help confirm the requested identity, align the specification with the intended synthesis, and coordinate the appropriate packaging and documentation requirements. I avoid making unsupported claims about batch performance, certification, or regulatory status unless those details are verified for the specific lot and destination.

For an accurate quotation, I recommend sending the required quantity, destination country, target specification, preferred packaging, and any documentation requirements. If the customer has a reaction scheme, impurity concern, or moisture limit, including that information can make the technical review more efficient. Depending on the requested quantity and available stock, the commercial team can then discuss sample supply, bulk options, lead time, and shipping arrangements.

Key Takeaways

• 4-Aminophenylboronic acid picol ester CAS 214360-73-3 is an aromatic boronic ester building block with a para-amino group.
• Its main synthetic role is to support aryl coupling and further functionalization in research and intermediate development.
• Buyers should verify the structure, CAS number, assay, water content, residual solvents, and analytical documentation.
• Commercial names can vary, so “picol ester” should be checked against the supplier’s structure and certificate of analysis.
• Maison Chemical can help coordinate product confirmation, specification review, packaging, and B2B export inquiries.

Conclusion: Is This the Right Building Block for Your Project?

4-Aminophenylboronic acid picol ester CAS 214360-73-3 is a useful choice when a synthesis requires both a para-amino aromatic group and a protected boron coupling handle. Its suitability depends on the exact structure, purity requirement, reaction conditions, moisture tolerance, and downstream process. I recommend beginning with identity confirmation and a small-scale technical evaluation before moving to larger quantities.

As the next step, send Maison Chemical your required quantity, target purity, delivery destination, and any preferred analytical or packaging conditions. I can then help review the specification and prepare a practical B2B supply proposal based on the actual project requirements.

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