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Horny goat weed has been a significant component of traditional Asian medicine for over 1,000 years, recognized especially as a yang tonic that relates to the "energetic organ" of the kidney, which somewhat aligns with the Western understanding of the kidney's role. Enhancing kidney energy in this context is believed to improve sexual performance and fertility. Various animal studies conducted in China have substantiated the effectiveness of this herb concerning its traditional use as a yang tonic. Additionally, horny goat weed is reputed to alleviate what is termed wind-damp-cold, which interferes with the circulation of the body's vital energy, or qi. This concept parallels some Western medical concerns such as atherosclerosis and similar conditions, and it is particularly noted for aiding recovery in stroke patients.
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In the realm of traditional Asian herbal medicine, it is common for herbs to be utilized in multi-herb formulations rather than in isolation. A specific animal study in China demonstrated that a composite of horny goat weed combined with three other herbs effectively reduced osteoporosis induced by cortisone-like drugs, while each herb alone showed no significant effects. This reinforces the traditional belief that horny goat weed may yield more considerable benefits when integrated with other herbal ingredients.
Horny goat weed is rich in various flavonoids, some of which exhibit estrogen-inhibiting properties in laboratory settings. These hormonal interactions may contribute to its historical application in treating sexual dysfunction, revealing efficacy in clinical trials involving patients with kidney failure by boosting sexual drive. Furthermore, certain flavonoids in horny goat weed, like icariin, have been found to stimulate bone-building cells (osteoblasts). Research indicates that rats administered with horny goat weed extracts showed protection against osteoporosis. Additionally, several flavonoids have demonstrated immune-modulating effects that can either stimulate or suppress immune function depending on the conditions tested. Preliminary findings from human trials involving patients with kidney disease on dialysis suggest that horny goat weed may enhance several aspects of immune system functionality. Furthermore, icariin has been shown to protect liver cells in laboratory studies.
A water extract from horny goat weed has exhibited the ability to inhibit the formation of new blood vessels, a characteristic that could play a crucial role in hindering cancer progression. Extracts derived from the herb have also shown moderate efficiency in laboratory tests aimed at inhibiting cancer cell proliferation, though icariin alone was not effective in this regard. However, it did encourage some cancer cells to revert to a more normal state in vitro.
Lignans also appear in various types of horny goat weed, with some demonstrated in one animal study to stimulate nerve growth.
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Moreover, research indicates that when combined with three other herbs, horny goat weed has inhibited inflammation in several animal studies. This finding may partly clarify the observed effectiveness of compositions containing horny goat weed in preliminary studies regarding hay fever treatment. The immune effects attributed to the flavonoids might also pertain to this efficacy.
Water extracts of horny goat weed have been demonstrated to effectively impede the herpes simplex virus in laboratory conditions. Furthermore, such extracts have been noted to lower blood pressure across several animal models and contribute to a reduction in cholesterol levels. These extracts have also shown beneficial effects when used alongside various other herbs in individuals exhibiting what traditional Chinese medicine terms kidney yang deficiency, analogous to what Western medicine may interpret as arterial hardening contributing to dementia. Notably, this formula yielded more significant results than formulas lacking horny goat weed, with the success linked to antioxidant, cholesterol-lowering, and anti-inflammatory properties observed in participants taking the horny goat weed-inclusive formula.
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