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This document provides answers to common questions about capsule filling processes. It discusses how to determine the appropriate capsule size for a formulation based on density and fill weight. It also describes how to establish proper filling limits and effectively monitor processes using statistical process control techniques like control charts. Ensuring quality involves checking for defects after machine setup and repairs using a large sample size. Key factors for effective high-speed filling include formulations that lubricate well, compact efficiently, and flow uniformly. Some formulations like those that are moisture sensitive or hygroscopic may not be suitable for two-piece gelatin capsules.
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